![]() ![]() 1 As a result, individuals with T1D require uninterrupted exogenous insulin therapy to maintain their health and prevent severe metabolic complications, such as ketoacidosis. The resulting absolute insulin deficiency causes hyperglycemia (high glucose levels), as well as changes in protein and lipid metabolism. Type 1 diabetes (T1D) is an autoimmune disease that results in loss of insulin-producing beta cells of the pancreatic islets.
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